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LDN for Adrenal Fatigue – A Story From Amir

LDN for Adrenal Fatigue – A Story From Amir

Amir, 43, came to see me after being referred by his nutritionist who was seeing him for adrenal fatigue. He is a professional who came upon some hard times which affected him badly.

He was on quite a few supplements for his fatigue and showed some signs of hormonal imbalance. I also thought that his diet was quite poor which would affect him quite significantly. He had brain fog, constant fatigue, struggled to recover from exercise, was moody and depressed and could not sleep well.

Amir’s story, in his words…

“Hi Dr Bains,

Thank you very much for your help and support. It has been a real life saver.

Prior to this adrenal fatigue, I was very fit and healthy, exercised 4 times a week, and was successful. An abusive marriage, mom dying and extreme stress caused me to become ill and life has been a struggle since 2003. Three years ago, after finishing an MBA,  I crashed completely and started work with a nutrionist making slow progress.  Prior to the LDN, my energy levels were very very low to non existent,  my mood was very low to depressed, I struggled to get 5-6 hours very poor quality sleep, and woke up feeling unrefreshed with high adrenaline levels. I felt like a zombie ,put on weight, was unable to think straight, had very bad brain fog, and was unable to do anything due to very low energy levels.

The turnaround with LDN has been nothing short of miraculous, and a real game changer.

We started the dose at 3mg, and things got worse before they got better. The LDN really ramped up an already primed immune system, increased my adrenaline, caused flu and cold like symptoms, i.e. phlegm from nose and chest, aches and pains, especially back ache, skin was horrendous and sleep was very poor due to the increased adrenaline.  However, 2 weeks after this, the immune system settled and my sleep went from 5 hours to 7 hours, and sleep quality improved from 5 to 6 out of 10. After letting the body rest and recover for 2 weeks, we increased the LDN again, causing the same cycle, but each time resulting in slightly improved sleep. Now at 5mg and after 4 months, the turnaround has been dramatic. I can sleep for 9 – 11 hours, of good quality sleep ( 8 out of 10 ), and things are improving at a faster rate. Energy levels are higher, brain fog has lifted, and most dramatic of all, my mood has improved 100%. I no longer feel depressed, despite being sub-optimal. I wake up happier, relaxed, and with a positive mindset, excited about the future.

The key to LDN was definitely perseverance. Each stage caused initial upset, and then the reward phase followed. The big pay off being 4 months down the line. Definitely worth the wait.

Without your help, I would not have made this breakthrough.

I am now hoping to proceed to the next level of the program with my nutritionalist, and start the anti-microbial phase, and to be able to tolerate it well, due to the LDN and enhanced sleep.

I have taken the advice you provided 4 months ago and incorporated healthy fats into my diet, started cooking with coconut oil,  watched YouTube videos and vastly improved my cooking skills. I’m struggling to add in fermented foods, and this is something my nutritionist is keen to do at a later stage.

I will now look into SIBO and get back to you.”

Resources:

  1. Brown, Norman, and Jaak Panksepp. “Low-Dose Naltrexone for Disease Prevention and Quality of Life.” Medical Hypotheses, vol. 72, no. 3, 2009, pp. 333–337., doi:10.1016/j.mehy.2008.06.048.

  2. Debasish Hota, Anand Srinivasan, Pinaki Dutta, Anil Bhansali, Amitava Chakrabarti, Off-Label, Low-Dose Naltrexone for Refractory Painful Diabetic Neuropathy, Pain Medicine, Volume 17, Issue 4, April 2016, Pages 790–791, https://doi.org/10.1093/pm/pnv009

  3. Jaros BA, Joanna and Peter Lio MD. “Low Dose Naltrexone in Dermatology.” Journal of Drugs in Dermatology. 18.3 (2019): 235-238.

  4. Metyas, Samy K, et al. “Low Dose Naltrexone in the Treatment of Fibromyalgia.” Current Rheumatology Reviews, vol. 14, no. 2, 2018, pp. 177–180., doi:10.2174/1573397113666170321120329.

  5. Mischoulon, David, et al. “Randomized, Proof-of-Concept Trial of Low Dose Naltrexone for Patients with Breakthrough Symptoms of Major Depressive Disorder on Antidepressants.” Journal of Affective Disorders, vol. 208, 2017, pp. 6–14., doi:10.1016/j.jad.2016.08.029.

  6. Parker, Claire E et al. “Low dose naltrexone for induction of remission in Crohn’s disease.” The Cochrane database of systematic reviews vol. 4,4 CD010410. 1 Apr. 2018, doi:10.1002/14651858.CD010410.pub3

  7. Patten, Denise K., et al. “The Safety and Efficacy of Low-Dose Naltrexone in the Management of Chronic Pain and Inflammation in Multiple Sclerosis, Fibromyalgia, Crohns Disease, and Other Chronic Pain Disorders.” Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, vol. 38, no. 3, 2018, pp. 382–389., doi:10.1002/phar.2086.

  8. Smith, Jill P., et al. “Low-Dose Naltrexone Therapy Improves Active Crohns Disease.” The American Journal of Gastroenterology, vol. 102, no. 4, 2007, pp. 820–828., doi:10.1111/j.1572-0241.2007.01045.x.

  9. William Raffaeli, Paola Indovina, Low-Dose Naltrexone to Prevent Intolerable Morphine Adverse Events: A Forgotten Remedy for a Neglected, Global Clinical Need, Pain Medicine, Volume 16, Issue 6, June 2015, Pages 1239–1242, https://doi.org/10.1111/pme.12704

  10. Younger, Jarred et al. “The use of low-dose naltrexone (LDN) as a novel anti-inflammatory treatment for chronic pain.” Clinical rheumatology vol. 33,4 (2014): 451-9. doi:10.1007/s10067-014-2517-2

  11. Zashin, Scott. “Sjogren’s Syndrome: Clinical Benefits of Low-dose Naltrexone Therapy.” Cureus vol. 11,3 e4225. 11 Mar. 2019, doi:10.7759/cureus.4225

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